PREVENTION OF PROTEIN EXTRAVASATION IN THE BRAIN BY AN ANION TRANSPORT INHIBITOR IN ACUTE EXPERIMENTAL-HYPERTENSION IN RATS

被引：13

作者：

HANSSON, HA ^{[1
]}

JOHANSSON, BB ^{[1
]}

机构：

[1] GOTHENBURG UNIV,FAC MED,DEPT NEUROL,S-40260 GOTHENBURG,SWEDEN

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1979年 / 105卷 / 04期

关键词：

Acute hypertension; anion transport inhibitor; blood brain barrier; dexamethasone; pinocytosis; protein tracers;

D O I：

10.1111/j.1748-1716.1979.tb00116.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Acute experimental hypertension induces protein leakage in the brain. The protein is thought to be, at least to a great extent, transported through the endothelial cells by pinocytosis. An anion transport inhibitor, 4 acetamido‐4‐isothiocyano‐stilbene‐2,2′‐disulfonic acid, markedly reduced adrenaline or bicuculline‐induced leakage of 125IHSA and Evans blue‐albumin in all areas of the rat brain. The preventive effect of dexamethasone was less pronounced and no effect was seen of haloperidol. © 1979 Scandinavian Physiological Society

引用

页码：513 / 517

页数：5

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