SPECIES VARIATION IN BRDURD-INDUCED SISTER-CHROMATID EXCHANGES

被引:28
作者
MCFEE, AF
SHERRILL, MN
机构
[1] Comparative Animal Research Laboratory, Oak Ridge
来源
MUTATION RESEARCH | 1979年 / 62卷 / 01期
关键词
D O I
10.1016/0027-5107(79)90226-4
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Peripheral blood lymphocytes from cattle, pigs, sheep and humans were cultured in the presence of 0.5, 1, 2, 5,10 or 20 μg/ml of BrdUrd. Sister-chromatid exchanges were scored in 25 second-division metaphases from each donor at each level of the chemical. Dose-response curves for all 4 species increased steeply to 2 μg/ml; above this level, SCE numbers increased less rapidly but maintained a linear relationship to increasing BrdUrd concentration. Comparisons of the straight-line portions of the dose-response curves showed human cells to be significantly more sensitive to increasing BrdUrd level than cow or pig cells and different from sheep at the 10% level of confidence. © 1979.
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页码:131 / 138
页数:8
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