CYCLOPHOSPHAMIDE AND IPHOSPHAMIDE AGAINST LEWIS LUNG-CARCINOMA - EVALUATION OF TOXIC AND THERAPEUTIC EFFECTS

被引：15

作者：

GRECO, C ^{[1
]}

CORSI, A ^{[1
]}

CAPUTO, M ^{[1
]}

CAVALLARI, A ^{[1
]}

CALABRESI, F ^{[1
]}

机构：

[1] IST REGINA ELENA STUDIO & CURA TUMORI,DIV MED & EMATOL,VIALE REGINA ELENA 291,I-00161 ROMA,ITALY

来源：

TUMORI | 1979年 / 65卷 / 02期

关键词：

D O I：

10.1177/030089167906500205

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the present report, investigations have been carried out to evaluate toxic and therapeutic effects of cyclophosphamide vs its isomer iphosphamide. Cytostatic action of the 2 drugs was assayed on the murine Lewis lung carcinoma (3LL). It has been observed that iphosphamide is less toxic as compared to cyclophosphamide (LD50 IP/LD50 CP=1.5); on the other hand, to reach the same therapeutic effectiveness on 3LL, an iphosphamide dose 1.6 - 2 times higher than that of its parent compound is necessary.

引用

页码：169 / 180

页数：12

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