NOVEL SOFT STEROIDS - EFFECTS ON CELL-GROWTH INVITRO AND ON WOUND-HEALING IN THE MOUSE

被引：14

作者：

BODOR, NS ^{[1
]}

KISSBURIS, ST ^{[1
]}

BURIS, L ^{[1
]}

机构：

[1] DEBRECEN UNIV MED, DEPT LEGAL MED, H-4012 DEBRECEN, HUNGARY

来源：

STEROIDS | 1991年 / 56卷 / 08期

关键词：

SOFT STEROIDS; LOTEPREDNOL ETABONATE; WOUND HEALING; CELL GROWTH; MOUSE;

D O I：

10.1016/0039-128X(91)90032-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evaluation of three "soft" steroids is described. The test compounds were compared with the standard anti-inflammatory steroids betamethasone and prednicarbate in two studies. Soft steroids are designed based on the "inactive metabolite approach" to be rapidly inactivated by predictable metabolism after performing their therapeutic function. Consequently, lower circulating (peripheral) levels of potentially harmful steroids result, and undesirable systemic and local side effects are minimized. The soft and standard steroids behaved similarly in an in vitro cell culture model, whereas in a whole animal study the advantages of the soft steroids were evident.

引用

页码：434 / 439

页数：6

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