The NIH Extracellular RNA Communication Consortium

被引：51

作者：

Ainsztein, Alexandra M. ^{[1
]}

Brooks, Philip J. ^{[2
]}

Dugan, Vivien G. ^{[3
]}

Ganguly, Aniruddha ^{[4
]}

Guo, Max ^{[5
]}

Howcroft, T. Kevin ^{[6
]}

Kelley, Christine A. ^{[7
]}

Kuo, Lillian S. ^{[8
]}

Labosky, Patricia A. ^{[9
]}

Lenzi, Rebecca ^{[9
]}

Mckie, George A. ^{[10
]}

Mohla, Suresh ^{[11
]}

Procaccini, Dena ^{[12
]}

Reilly, Matthew ^{[13
]}

Satterlee, John S. ^{[12
]}

Srinivas, Pothur R. ^{[14
]}

Church, Elizabeth Stansell ^{[15
]}

Sutherland, Margaret ^{[16
]}

Tagle, Danilo A. ^{[8
]}

Tucker, Jessica M. ^{[17
]}

Venkatachalam, Sundar ^{[18
]}

机构：

[1] NIGMS, Div Cell Biol & Biophys, Bethesda, MD USA

[2] Natl Ctr Adv Translat Sci NCATS, Div Clin Innovat, Bethesda, MD USA

[3] NIAID, Off Genom & Adv Technol, Div Microbiol & Infect Dis, Rockville, MD USA

[4] NCI, Canc Diag Program, Div Canc Treatment & Diag, Rockville, MD 20850 USA

[5] NIA, Genet & Cell Biol Branch, Div Aging Biol, Bethesda, MD 20892 USA

[6] NCI, Div Canc Biol, Canc Immunol & Hematol Branch, 9609 Med Ctr Dr,Room 6W560, Rockville, MD 20850 USA

[7] NIBIB, Div Discovery Sci & Technol, Bethesda, MD USA

[8] Natl Ctr Adv Translat Sci NCATS, Bethesda, MD USA

[9] NIH, Off Strateg Coordinat, Div Program Coordinat Planning & Strateg Initiat, Bethesda, MD 20892 USA

[10] NEI, Ocular Infect Inflammat & Immunol, Rockville, MD USA

[11] NCI, Div Canc Biol, Tumor Biol & Metastasis Branch TBMB, Rockville, MD 20850 USA

[12] NIDA, Rockville, MD USA

[13] NIAAA, Div Neurosci & Behav, Rockville, MD 20852 USA

[14] NHLBI, Div Cardiovasc Sci, Bethesda, MD 20892 USA

[15] NIAID, Pathogenesis & Basic Res Branch, Div Aids, Rockville, MD USA

[16] NINDS, Neurodegenerat Cluster, Rockville, MD USA

[17] NIBIB, Bethesda, MD USA

[18] Natl Inst Dent & Craniofacial Res NIDCR, Integrat Biol & Infect Dis Branch, Bethesda, MD USA

来源：

JOURNAL OF EXTRACELLULAR VESICLES | 2015年 / 4卷

关键词：

ERCC; exRNA; extracellular RNA;

D O I：

10.3402/jev.v4.27493

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The Extracellular RNA (exRNA) Communication Consortium, funded as an initiative of the NIH Common Fund, represents a consortium of investigators assembled to address the critical issues in the exRNA research arena. The overarching goal is to generate a multi-component community resource for sharing fundamental scientific discoveries, protocols, and innovative tools and technologies. The key initiatives include (a) generating a reference catalogue of exRNAs present in body fluids of normal healthy individuals that would facilitate disease diagnosis and therapies, (b) defining the fundamental principles of exRNA biogenesis, distribution, uptake, and function, as well as development of molecular tools, technologies, and imaging modalities to enable these studies, (c) identifying exRNA biomarkers of disease, (d) demonstrating clinical utility of exRNAs as therapeutic agents and developing scalable technologies required for these studies, and (e) developing a community resource, the exRNA Atlas, to provide the scientific community access to exRNA data, standardized exRNA protocols, and other useful tools and technologies generated by funded investigators.

引用

页数：6