MAXIMUM-LIKELIHOOD-ESTIMATION AND IDENTIFICATION DIRECTLY FROM SINGLE-CHANNEL RECORDINGS

被引：107

作者：

FREDKIN, DR ^{[1
]}

RICE, JA ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY, DEPT STAT, BERKELEY, CA 94720 USA

来源：

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1992年 / 249卷 / 1325期

关键词：

D O I：

10.1098/rspb.1992.0094

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present a method for analysis of noisy sampled data from a single-channel patch clamp which bypasses restoration of an idealized quantal signal. We show that, even in the absence of a specific model, the conductance levels and mean dwell times within those levels can be estimated. Estimation of the rate constants of a hypothesized kinetic scheme is more difficult. We present examples in which the rate constants can be effectively estimated and examples in which they cannot.

引用

页码：125 / 132

页数：8

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