ENZYMATIC RESOLUTION OF AMPA BY USE OF ALPHA-CHYMOTRYPSIN

被引：14

作者：

NIELSEN, B

FISKER, H

EBERT, B

MADSEN, U

CURTIS, DR

KROGSGAARDLARSEN, P

HANSEN, JJ

机构：

[1] ROYAL DANISH SCH PHARM,DEPT ORGAN CHEM,PHARMABIOTEC RES CTR,DK-2100 COPENHAGEN,DENMARK

[2] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,CANBERRA,ACT 2601,AUSTRALIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80102-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The enantiomers of AMPA and its diethyl derivative were prepared by an enzymatic resolution using alpha-chymotrypsin in solution. Electrophysiological studies in vivo and in vitro showed the excitatory effects of AMPA to reside mainly in the L-enantiomer in agreement with the IC50 values of 0.02 muM and 76 muM observed for the L- and D-enantiomer, respectively, in [H-3]AMPA binding assays.

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页码：107 / 114

页数：8

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