BOMBESIN AND GASTRIN-RELEASING PEPTIDE STIMULATE ELECTROGENIC ION-TRANSPORT IN CULTURED HUMAN ENDOMETRIAL EPITHELIAL-CELL LAYERS

被引：16

作者：

MATTHEWS, CJ ^{[1
]}

REDFERN, CPF ^{[1
]}

THOMAS, EJ ^{[1
]}

HIRST, BH ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT MED,NEWCASTLE TYNE NE2 4HH,ENGLAND

来源：

EXPERIMENTAL PHYSIOLOGY | 1993年 / 78卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1113/expphysiol.1993.sp003720

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Electrogenic ion transport across human endometrial epithelial cells grown as polarized monolayers on permeable supports was measured as an inward short-circuit current (I(SC); 16.2+/-1.1 muA/cm2). Bombesin (10(-7) m) and human gastrin-releasing peptide (GRP; 10(-7) M) caused transient enhancement of this I(SC). These effects were largely restricted to the basolateral surface of the cells; responses to apical peptide were modest in comparison with those to basolateral peptide. GRP and other bombesin-related peptides may have a role in regulation of endometrial epithelial ion transport in vivo and thereby influence the intra-uterine environment.

引用

页码：715 / 718

页数：4

共 6 条

[1] BOMBESIN AND BRADYKININ INCREASE INOSITOL PHOSPHATES AND CYTOSOLIC FREE CA2+, AND STIMULATE DNA-SYNTHESIS IN HUMAN ENDOMETRIAL STROMAL CELLS [J].

ENDO, T ;

FUKUE, H ;

KANAYA, M ;

MIZUNUMA, M ;

FUJII, M ;

YAMAMOTO, H ;

TANAKA, S ;

HASHIMOTO, M .

JOURNAL OF ENDOCRINOLOGY, 1991, 131 (02) :313-318

[2]

MATTHEWS CJ, 1992, FERTIL STERIL, V57, P990

[3] BRADYKININ STIMULATION OF ELECTROGENIC ION-TRANSPORT IN EPITHELIAL LAYERS OF CULTURED HUMAN ENDOMETRIUM [J].

MATTHEWS, CJ ;

MCEWAN, GTA ;

REDFERN, CPF ;

THOMAS, EJ ;

HIRST, BH .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1993, 422 (04) :401-403

[4]

MATTHEWS CJ, 1992, J PHYSIOL-LONDON, V446, pP97

[5]

MATTHEWS CJ, 1993, IN PRESS HUMAN REPRO

[6] NEURONAL LOCALIZATION AND MOTOR EFFECTS OF GASTRIN-RELEASING PEPTIDE (GRP) IN RAT UTERUS [J].

STJERNQUIST, M ;

EKBLAD, E ;

OWMAN, C ;

SUNDLER, F .

REGULATORY PEPTIDES, 1986, 13 (3-4) :197-205

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