SYNTHESIS AND BIOLOGICAL-ACTIVITY OF METHYL-D-GLUCOPYRANOSIDE DERIVATIVES OF MERCAPTOPURINE AND MERCAPTOPYRIMIDINE

被引：25

作者：

DASILVA, AD

MACHADO, AS

TEMPETE, C

ROBERTGERO, M

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

[2] UNIV FED MINAS GERAIS,DEPT QUIM,BR-31270 BELO HORIZONT,MG,BRAZIL

[3] UNIV FED JUIZ DE FORA,DEPT QUIM,BR-36100 JUIZ DE FORA,MG,BRAZIL

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 29卷 / 02期

关键词：

CARBOHYDRATE; MERCAPTOPURINE; ANTIPARASITIC ACTIVITY; ANTITUMOR ACTIVITY; CYTOTOXICITY;

D O I：

10.1016/0223-5234(94)90212-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Methyl 6'-deoxy-6'-(6-mercaptopurine or 2-mercaptopyrimidine)-alpha-D-glucopyranosidesand some of their derivatives, such as sulfoxides, were synthesized. Of the 9 molecules obtained, 2 exhibited a significant growth inhibitory effect on mammalian cells and parasites.

引用

页码：149 / 152

页数：4

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