BUSPIRONE ANALOGS AS LIGANDS OF THE 5-HT1A RECEPTOR .1. THE MOLECULAR-STRUCTURE OF BUSPIRONE AND ITS 2 ANALOGS

被引：45

作者：

CHILMONCZYK, Z

LES, A

WOZNIAKOWSKA, A

CYBULSKI, J

KOZIOL, AE

GDANIEC, M

机构：

[1] UNIV WARSAW,DEPT CHEM,PL-02093 WARSAW,POLAND

[2] MARIE CURIE SKLODOWSKA UNIV,DEPT CHEM,PL-20031 LUBLIN,POLAND

[3] ADAM MICKIEWICZ UNIV POZNAN,DEPT CHEM,PL-60780 POZNAN,POLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 38卷 / 10期

关键词：

D O I：

10.1021/jm00010a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An interdisciplinary (X-ray, H-1 and C-13 NMR, IR, and theoretical quantum mechanical) study on the potent 5-HT1A receptor ligand buspirone (1) and its two structural analogues, mesmar (4,4-dimethyl-1-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-2,6-piperidinedione) (2) and kaspar (8-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione) (3), has been reported. The results have shown that buspirone-like molecules should appear in an extended rod-shape form, possessing several potential interaction sites with the receptor.

引用

页码：1701 / 1710

页数：10

共 44 条

[1] 3-D QSAR FOR INTRINSIC ACTIVITY OF 5-HT(1A) RECEPTOR LIGANDS BY THE METHOD OF COMPARATIVE MOLECULAR-FIELD ANALYSIS [J].