EXPLANATIONS FOR HIGH-RATES OF ERADICATION WITH TRIPLE THERAPY USING METRONIDAZOLE IN PATIENTS HARBORING METRONIDAZOLE-RESISTANT HELICOBACTER-PYLORI STRAINS

被引：34

作者：

VANZWET, AA ^{[1
]}

THIJS, JC ^{[1
]}

DEGRAAF, B ^{[1
]}

机构：

[1] BETHESDA HOSP HOOGEVEEN,DEPT INTERNAL MED,HOOGOVENS,NETHERLANDS

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 01期

关键词：

D O I：

10.1128/AAC.39.1.250

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In 4 of 17 Helicobacter pylori strains obtained from antral biopsy samples, the registered primary resistance (MIC, >32 mu g/ml) appeared to be nonstable after prolonged microaerophilic incubation. In all resistant strains tested, susceptibility could be obtained when culture under normal microaerophilic conditions was preceded by a period of anaerobic incubation. Both of these findings may explain the observed discrepancy between the results of in vitro susceptibility tests and the eradication obtained in vivo.

引用

页码：250 / 252

页数：3

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