DISTINCT XP11.2 BREAKPOINTS IN 2 RENAL-CELL CARCINOMAS EXHIBITING X-AUTOSOME TRANSLOCATIONS

被引：64

作者：

DIJKHUIZEN, T

VANDENBERG, E

WILBRINK, M

WETERMAN, M

VANKESSEL, AG

STORKEL, S

FOLKERS, RP

BRAAM, A

DEJONG, B

机构：

[1] UNIV NIJMEGEN HOSP,DEPT HUMAN GENET,6500 HB NIJMEGEN,NETHERLANDS

[2] UNIV MAINZ,INST PATHOL,W-6500 MAINZ,GERMANY

来源：

GENES CHROMOSOMES & CANCER | 1995年 / 14卷 / 01期

关键词：

D O I：

10.1002/gcc.2870140108

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several human renal cell carcinomas with X;autosome translocations have been reported in recent years. The t(X; I)(p11.2;q21) appears to be a specific primary anomaly, suggesting that tumors with this translocation form a distinct subgroup of RCC. Here we report two new cases, one with a t(X;10)(p11.2;q23), the other with a t(X;1)(p11.2;p34). The common breakpoint in Xp11.2 suggests that they belong to the above-mentioned subset of RCC. Using FISH in conjunction with X-specific YAC clones, we demonstrate that the two new cases exhibited distinct breakpoints within Xp11.2. (C) 1995 Wiley-Liss, Inc.

引用

页码：43 / 50

页数：8

共 20 条

[1] IDENTIFICATION OF NOVEL GENES, SYT AND SSX, INVOLVED IN THE T(X18)(P11.2Q11.2) TRANSLOCATION FOUND IN HUMAN SYNOVIAL SARCOMA [J].