GROWTH-KINETICS OF A RAT MAMMARY-TUMOR TRANSPLANTED INTO IMMUNE-SUPPRESSED MICE

被引:8
作者
FU, KK
STEEL, GG
机构
[1] INST CANC RES,DIV BIOPHYS,SUTTON SM2 5PX,SURREY,ENGLAND
[2] INST CANC RES,DIV RADIOTHERAPY,SUTTON SM2 5PX,SURREY,ENGLAND
来源
CELL AND TISSUE KINETICS | 1979年 / 12卷 / 05期
关键词
D O I
10.1111/j.1365-2184.1979.tb00171.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The growth kinetics of a transplanted rat mammary tumour and its xenografts in immune‐suppressed mice were studied using the technique of labelled mitoses. Growth of the tumour in rats was regular and uniform but when transplanted into mice the growth of the implants was irregular and generally slower. The second passage tumours in mice showed rapid and regular growth with a volume doubling time approximately half that for the tumours in the rat. Values for the G1 phase duration, intermitotic time and growth fraction were greater for the tumours in the mouse although the data for the first passage in mice were difficult to interpret. The kinetic changes between the rat and mouse hosts primarily reflect a large and variable amount of cell loss from the first passage xenografts in the mouse, with adaptation by the second passage towards reduced cell loss. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码:493 / 499
页数:7
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