EFFECT OF STRESS, ADRENOCORTICOTROPIN OR CORTICOSTEROID TREATMENT, ADRENALECTOMY, OR HYPOPHYSECTOMY ON HYPOTHALAMIC IMMUNOREACTIVE ADRENOCORTICOTROPIN CONCENTRATIONS

被引：69

作者：

KRIEGER, DT ^{[1
]}

LIOTTA, AS ^{[1
]}

HAUSER, H ^{[1
]}

BROWNSTEIN, MJ ^{[1
]}

机构：

[1] NIMH,CLIN SCI LAB,BETHESDA,MD 20014

来源：

ENDOCRINOLOGY | 1979年 / 105卷 / 03期

关键词：

D O I：

10.1210/endo-105-3-737

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite variations in plasma and/or pituitary ACTH concentrations, no changes in median eminence or medial basal hypothalamic immunoreactive ACTH-like concentrations were seen in rats studied 6 weeks posthypophysectomy, 12 h or 28 days after bilateral adrenalectomy, 6 days after implantation of corticosterone pellets (75 mg), after dexamethasone administration (300 μg/100 g BW, ip, twice daily for 4 days), or after chronic immobilization stress. The lack of concordant variation of brain, pituitary, and plasma ACTH concentrations further supports the suggestion of a nonpituitary, central nervous system origin of some portion of brain immunoreactive ACTH-like activity. © 1979 by The Endocrine Society.

引用

页码：737 / 742

页数：6

共 38 条

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