OLEIC-ACID REVERSIBLY OPENS THE BLOOD-BRAIN-BARRIER

被引：38

作者：

SZTRIHA, L

BETZ, AL

机构：

[1] UNIV MICHIGAN,DEPT SURG,D3222 MED PROFESS BLDG,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,DEPT PEDIAT,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN,DEPT NEUROL,ANN ARBOR,MI 48109

[4] SZENT GYORGYI MED SCH,DEPT PEDIAT,SZEGED,HUNGARY

来源：

BRAIN RESEARCH | 1991年 / 550卷 / 02期

关键词：

OLEIC ACID; BLOOD-BRAIN BARRIER; ALPHA-AMINOISOBUTYRIC ACID PERMEABILITY SURFACE AREA PRODUCT; PERMEABILITY; BARRIER MODIFICATION;

D O I：

10.1016/0006-8993(91)91326-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examined the effect of intracarotid oleic acid infusion on blood-brain barrier permeability. Oleic acid was infused for 30 s at a rate of 6 ml/min into the right internal carotid artery at concentrations of 10(-6), 10(-5), 2 x 10(-5) and 5 x 10(-5) M. Extensive Evans blue-albumin extravasation was observed 15 min after the administration of 2 x 10(-5) M oleic acid. The permeability surface area product for alpha-aminoisobutyric acid (AIB), determined 1-11 min following the infusion of oleic acid was increased 10-fold following infusion of 10(-5) M oleic acid and 20-fold following the administration of 5 x 10(-5) M oleate. The blood-brain barrier opening to AIB proved to be reversible 80-90 min after the infusion of 2 x 10(-5) M oleic acid. The possible mechanisms of the oleic acid effect are discussed.

引用

页码：257 / 262

页数：6

共 30 条

[1] RELEASE OF GLUTAMATE AND OF FREE FATTY-ACIDS IN VASOGENIC BRAIN EDEMA [J].