GROWTH-PROMOTING ACTIVITY OF TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) FOR A WIDE-RANGE OF CELLS - A POSSIBLE NEW GROWTH-FACTOR IN SERUM

被引：614

作者：

HAYAKAWA, T

YAMASHITA, K

TANZAWA, K

UCHIJIMA, E

IWATA, K

机构：

[1] SANKYO CO LTD, FERMENTAT RES LABS, SHINAGAWA KU, TOKYO 140, JAPAN

[2] FUJI CHEM IND CO LTD, TAKAOKA, TOYAMA 933, JAPAN

来源：

FEBS LETTERS | 1992年 / 298卷 / 01期

关键词：

TISSUE INHIBITOR OF METALLOPROTEINASE (TIMP-1 AND TIMP-2); CELL-GROWTH PROMOTING ACTIVITY; SERUM GROWTH FACTOR; HUMAN CELL; BOVINE CELL;

D O I：

10.1016/0014-5793(92)80015-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human tissue inhibitor of metalloproteinases-1 (TIMP-1), but not TIMP-2, has potent growth-promoting activity for a wide range of human and bovine cells. TIMP-1 seems to be a new cell-growth factor in serum and to stimulate the cells independently of its inhibitory activity.

引用

页码：29 / 32

页数：4

共 23 条

[1]

AVALOS BR, 1988, BLOOD, V71, P1720

[2]

Cawston T.E., 1986, PROTEINASE INHIBITOR, P589

[3]

DECLERCK YA, 1991, J BIOL CHEM, V266, P3893

[4]

DECLERCK YA, 1989, J BIOL CHEM, V264, P17445