IDENTIFICATION OF A SMALL RNA THAT INTERACTS WITH THE 5' SPLICE-SITE OF THE TRYPANOSOMA-BRUCEI SPLICED LEADER RNA IN-VIVO

被引:41
作者
WATKINS, KP
DUNGAN, JM
AGABIAN, N
机构
[1] University of California, San Francisco
[2] University of California, Berkeley
关键词
D O I
10.1016/0092-8674(94)90181-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In vivo psoralen cross-linking of the trypanosome spliced leader (SL) RNA has led to the discovery of a small RNA that we provisionally call the spliced leader associated (SLA) RNA. The 72 nt SLA RNA is unlike any known small RNA except for a small region that resembles U5 snRNA. The SL/SLA RNA cross-links map to two regions, the predominant interactions occurring between the 5' splice site region of the SL RNA and a CUUUUA sequence in the SLA RNA. The resemblance between these cross-links and interactions of U5 snRNA with cis-spliced pre-mRNAs suggests that the SLA RNA may be the trans-splicing analog of U5 snRNA in trypanosomes.
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页码:171 / 182
页数:12
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