ETHANOL AND DIAZEPAM INHIBITION OF HIPPOCAMPAL LTP IS MEDIATED BY ANGIOTENSIN-II AND AT(1) RECEPTORS

被引：45

作者：

WAYNER, MJ

ARMSTRONG, DL

POLANCURTAIN, JL

DENNY, JB

机构：

[1] Division of Life Sciences, The University of Texas at San Antonio, San Antonio

来源：

PEPTIDES | 1993年 / 14卷 / 03期

关键词：

LONG-TERM POTENTIATION; INHIBITION; ANGIOTENSIN-II; HIPPOCAMPUS; GRANULE CELLS; ETHANOL; DIAZEPAM; SARALASIN; LORSARTAN;

D O I：

10.1016/0196-9781(93)90129-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiotensin II (AII) inhibits the induction of hippocampal long-term potentiation (LTP), a frequency-dependent model of learning and memory. These results demonstrate that the dose-dependent inhibition of LTP due to ethanol (EtOH) and diazepam (DZ) involves AII. Inhibition of LTP induction by All, EtOH, and DZ can be blocked by All receptor antagonists saralasin and lorsartan (DuP 753). Lorsartan is a competitive antagonist of the AT1 subtype All receptor. Therefore, the EtOH and DZ inhibition of LTP induction is mediated by AT1 receptors. These results indicate a new role for AII in the brain in the possible mediation of memory deficits associated with alcohol and the benzodiazepines.

引用

页码：441 / 444

页数：4

共 28 条

[1] EFFECTS OF DIAZEPAM ON HIPPOCAMPAL EXCITABILITY IN THE RAT - ACTION IN THE DENTATE AREA [J].