TRANSSYNAPTIC EXPRESSION OF A PRESYNAPTIC GLUTAMATE-RECEPTOR DURING HIPPOCAMPAL LONG-TERM POTENTIATION

被引:55
作者
SMIRNOVA, T
LAROCHE, S
ERRINGTON, ML
HICKS, AA
BLISS, TVP
MALLET, J
机构
[1] LAB GENET MOLEC & NEUROTRANSMISS & PROC, NEURODEGENERAT, CNRS, C9923, F-91198 GIF SUR YVETTE, FRANCE
[2] NATL INST MED RES, DIV NEUROPHYSIOL & NEUROPHARMACOL, LONDON NW7 1AA, ENGLAND
[3] UNIV PARIS 11, NEUROBIOL APPRENTISSAGE & MEMOIRE LAB, CNRS, URA 1491, F-91405 ORSAY, FRANCE
关键词
D O I
10.1126/science.8105538
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Repetitive activation of excitatory synapses in the hippocampus produces a persistent enhancement of synaptic efficiency known as long-term potentiation (LTP). In anesthetized and in freely moving rats, the induction of LTP in the perforant path led to a transient increase in the amount of messenger RNA (mRNA) coding for a presynaptic glutamate receptor (GR33) in dentate granule cells. The amount of GR33 mRNA was increased for at least 5 hours after the induction of LTP but was indistinguishable from control values 1 day after induction. The N-methyl-D-aspartate receptor antagonist 2-aminophosphonovalerate prevented the induction of both LTP and the increase in GR33 mRNA. The amount of GR33 protein was increased in the mossy fiber terminal zone of dentate granule cells 5 hours after the induction of LTP. These results suggest that the induction of LTP in synapses at one stage in a neural network may lead to modification in synaptic function at the next stage in the network.
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页码:433 / 436
页数:4
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