REGULATION OF LIVER METALLOTHIONEIN AND PLASMA ZINC BY THE GLUCOCORTICOID DEXAMETHASONE

被引：138

作者：

ETZEL, KR ^{[1
]}

SHAPIRO, SG ^{[1
]}

COUSINS, RJ ^{[1
]}

机构：

[1] RUTGERS STATE UNIV, DEPT NUTR, NEW BRUNSWICK, NJ 08903 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)92124-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Administration of the glucocorticoid dexamethasone to adrenalectomized rats significantly decreased the serum zinc concentration within 14 hr. Dexamethasone did not detectably alter the liver zinc content, but markedly increased the proportion of zinc associated with liver metallothionein. The rate of incorporation of 35S-cystine into this protein was stimulated to a maximal extent 7 hr after administration of the glucocorticoid. Poly(A)+ mRNA from liver polysomes was isolated and translated in a cell-free protein synthesizing system. Nearly twice as much polysomal metallothionein mRNA was found 7 hr following treatment with dexamethasone. These results suggest that glucocorticoids can regulate the plasma zinc concentration by a process that is related to the biosynthesis of the hepatic zinc-binding protein, metallothionein. © 1979.

引用

页码：1120 / 1126

页数：7

共 16 条

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