EFFECT OF 3 SEROTONIN ANTAGONISTS ON PLASMA PROLACTIN RESPONSE TO SUCKLING IN PUERPERAL WOMEN

被引：17

作者：

CROSIGNANI, PG

LOMBROSO, GC

MATTEI, A

CACCAMO, A

TROJSI, L

机构：

[1] Department of Obstetrics and Gynecology, University of Milan, Milan

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1979年 / 48卷 / 02期

关键词：

D O I：

10.1210/jcem-48-2-335

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of the acute administration of three serotonin antagonists on plasma PRL levels and on the PRL response to suckling was investigated in a group of puerperal women. A single oral dose of metergoline or methysergide induced a significant decrease of plasma PRL levels and abolished the PRL response to suckling. Cyproheptadine administration did not modify either the plasma PRL levels or the PRL response to suckling. These results are discussed in light of the known pharmacological properties of the three antiserotonergic drugs. © 1979 by The Endocrine Society.

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页码：335 / 337

页数：3

相关论文

共 19 条

[1] H-1 AND H-2 HISTAMINE RECEPTOR PARTICIPATION IN BRAIN CONTROL OF PROLACTIN SECRETION IN LACTATING RATS [J].

ARAKELIAN, MC ;

LIBERTUN, C .

ENDOCRINOLOGY, 1977, 100 (03) :890-895

[2]

BRUNDELR.R, 1973, OBSTET GYNECOL, V41, P884

[3] INHIBITORY EFFECT OF AN ERGOLINE DERIVATIVE, METHERGOLINE, ON GROWTH-HORMONE AND PROLACTIN LEVELS IN ACROMEGALIC PATIENTS [J].

CHIODINI, PG ;

LIUZZI, A ;

MULLER, EE ;

BOTALLA, L ;

CREMASCOLI, G ;

OPPIZZI, G ;

VERDE, G ;

SILVESTRINI, F .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1976, 43 (02) :356-363

[4] DOPAMINE RECEPTOR - DIFFERENTIAL BINDING OF D-LSD AND RELATED AGENTS TO AGONIST AND ANTAGONIST STATES [J].

CREESE, I ;

BURT, DR ;

SNYDER, SH .

LIFE SCIENCES, 1975, 17 (11) :1715-1719

[5]

CROSIGNANI PG, 1978, OBSTET GYNECOL, V51, P113

[6] ACTION OF METERGOLINE IN SUPPRESSING PROLACTIN-RELEASE INDUCED BY MECHANICAL BREAST EMPTYING [J].

DELITALA, G ;

LODICO, G ;

MASALA, A ;

ALAGNA, S ;

DEVILLA, L .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1977, 44 (04) :763-765

[7] METERGOLINE IN INHIBITION OF PUERPERAL LACTATION [J].

DELITALA, G ;

MASALA, A ;

ALAGNA, S ;

DEVILLA, L ;

LODICO, G ;

LOTTI, G .

BRITISH MEDICAL JOURNAL, 1977, 1 (6063) :744-746

[8]

ENJALBERT A, 1978, MOL PHARMACOL, V14, P11

[9] PROLACTIN SUPPRESSION BY SEROTONIN ANTAGONISTS IN MAN - FURTHER EVIDENCE FOR SEROTONINERGIC CONTROL OF PROLACTIN SECRETION [J].

FERRARI, C ;

CALDARA, R ;

ROMUSSI, M ;

RAMPINI, P ;

TELLOLI, P ;

ZAATAR, S ;

CURTARELLI, G .

NEUROENDOCRINOLOGY, 1978, 25 (06) :319-328

[10] PARTICIPATION OF SEROTONIN-CONTAINING NEURONS IN SUCKLING-INDUCED RISE IN PLASMA PROLACTIN LEVELS IN LACTATING RATS [J].

KORDON, C ;

BLAKE, CA ;

TERKEL, J ;

SAWYER, CH .

NEUROENDOCRINOLOGY, 1973, 13 (4-5) :213-223