INTRA-HEPATIC BILE-DUCT PROLIFERATION INDUCED BY 4,4'-DIAMINODIPHENYLMETHANE IN RATS

被引：29

作者：

FUKUSHIMA, S ^{[1
]}

SHIBATA, M ^{[1
]}

HIBINO, T ^{[1
]}

YOSHIMURA, T ^{[1
]}

HIROSE, M ^{[1
]}

ITO, N ^{[1
]}

机构：

[1] FUJITA GAKUEN UNIV,SCH MED TECHNOL & NURSING,DEPT PATHOL,AICHI 47011,JAPAN

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1979年 / 48卷 / 01期

关键词：

D O I：

10.1016/S0041-008X(79)80017-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prolonged intoxication with 1000 ppm of 4,4′-diaminodiphenylmethane (DDPM) led to hyperplasia of bile ducts and proliferation of oval cells. Hyperplastic areas gradually regressed and were replaced by fibrous tissue after cessation of DDPM administration. Elevation of γ-glutamic transpeptidase and alkaline phosphatase in serum accompanied the proliferation of bile ductular cells. © 1979 Academic Press, Inc. All rights reserved.

引用

页码：145 / 155

页数：11

共 30 条

[1] HISTOCHEMICAL DEMONSTRATION OF GAMMA-GLUTAMYL TRANSPEPTIDASE [J].

ALBERT, Z ;

ORLOWSKI, M ;

SZEWCZUK, A .

NATURE, 1961, 191 (479) :767-&

[2]

ALBERT Z, 1964, ACTA HISTOCHEM, V18, P78

[3] RECOVERY FROM THE BILE-DUCT HYPERPLASIA INDUCED BY FEEDING ALPHA-NAPHTHYL-ISOTHIOCYANATE TO RATS [J].

CAMERON, GR ;

MCLEAN, MR ;

PRASAD, LBM .

JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1960, 80 (01) :137-&

[4]

CANSTATT HBS, 1966, VERH DTSCH GES PATHO, V50, P429

[5]

FARBER E, 1956, CANCER RES, V16, P142

[6] EFFECT OF HEPATOTOXIC OR NEPHROTOXIC AGENTS ON INDUCTION OF COLON CANCERS IN RATS BY 1,2-DIMETHYLHYDRAZINE [J].

FUKUSHIMA, S ;

HIBINO, T ;

SHIBATA, M ;

MURASAKI, G ;

OGISO, T ;

ITO, N .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1977, 40 (03) :561-570

[7]

GRISHAM JW, 1961, LAB INVEST, V10, P317

[8] LIVER AND LUNG TUMORS AFTER 3,3INCHES-DICHLORO-4,4INCHES-DIAMINODIPHENYLMETHANE IN RATS [J].

GRUNDMANN, E ;

STEINHOFF, D .

ZEITSCHRIFT FUR KREBSFORSCHUNG, 1970, 74 (01) :28-+

[9] HISTOCHEMICAL DEMONSTRATION OF INCREASED ACTIVITY OF GAMMA-GLUTAMYL TRANSPEPTIDASE IN RAT-LIVER DURING HEPATOCARCINOGENESIS [J].

HARADA, M ;

OKABE, K ;

SHIBATA, K ;

MASUDA, H ;

MIYATA, K ;

ENOMOTO, M .

ACTA HISTOCHEMICA ET CYTOCHEMICA, 1976, 9 (02) :168-179

[10]

HATERSTRAND I, 1973, ACTA PATH MICROBIO A, V81, P737

← 1 2 3 →