FLEXIBLE AGLYCONE RESIDUES IN DUPLEX DNA

被引：22

作者：

FRANCOIS, P ^{[1
]}

PERILLEUX, D ^{[1
]}

KEMPENER, Y ^{[1
]}

SONVEAUX, E ^{[1
]}

机构：

[1] LAB BIOCHIM PHYS & BIOPOLYMERES,1 PL LOUIS PASTEUR,B-1348 LOUVAIN,BELGIUM

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(00)97060-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleotide analogues with a primary amide function attached by a polymethylene chain to C1 of 2-deoxy-D-ribofuranose were synthesized and incorporated into short double helices. The thermodynamic stability of these duplexes was studied. A higher melting temperature was observed when a hydrophobic hydrocarbon chain was attached to C1, instead of the more hydrophilic amide group. © 1990.

引用

页码：6347 / 6350

页数：4

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