DEVELOPMENTAL EXPRESSION OF G-PROTEINS THAT DIFFERENTIALLY MODULATE ADENYLYL CYCLASE ACTIVITY IN MOUSE-BRAIN

被引：31

作者：

RIUS, RA ^{[1
]}

STREATY, RA ^{[1
]}

LOH, YP ^{[1
]}

KLEE, WA ^{[1
]}

机构：

[1] NIMH,MOLEC BIOL LAB,BETHESDA,MD 20892

来源：

FEBS LETTERS | 1991年 / 288卷 / 1-2期

关键词：

DEVELOPMENT (MOUSE BRAIN); G-PROTEIN; ALTERNATIVE SPLICING; ADENYLYL CYCLASE; OPIATE RECEPTOR;

D O I：

10.1016/0014-5793(91)81001-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Changes in the relative abundance of the G protein alpha-subunits were observed during early mouse development G(s-alpha) was almost exclusively present as a large form (G(s-1)) in prenatal brain. Postnatally with a substantial increase in Gpp[NH]p stimulated adenylyl cyclase activity, the small form (G(s-s)) increased in amount while G(s-1) decreased. These results suggest that the G(s-s) may be the more effective cyclase activator and that changes in alternative splicing are developmentally regulated. G(i1) and G(o) appeared before birth whereas G(i2) developed postnatally. Opiate stimulation of GTPase and inhibition of adenylyl cyclase were fully expressed prenatally.

引用

页码：51 / 54

页数：4

共 44 条

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