DECREASE OF GABA-IMMUNOREACTIVE NEURONS IN THE AMYGDALA AFTER ELECTRICAL KINDLING IN THE RAT

被引：61

作者：

CALLAHAN, PM ^{[1
]}

PARIS, JM ^{[1
]}

CUNNINGHAM, KA ^{[1
]}

SHINNICKGALLAGHER, P ^{[1
]}

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT PHARMACOL & TOXICOL,GALVESTON,TX 77550

来源：

BRAIN RESEARCH | 1991年 / 555卷 / 02期

关键词：

AMYGDALA; GAMMA-AMINOBUTYRIC ACID; ELECTRICAL KINDLING; EPILEPSY; IMMUNOHISTOCHEMISTRY; RAT;

D O I：

10.1016/0006-8993(91)90361-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study was designed to investigate the effects of electrical kindling in vivo on GABA immunoreactivity (GABA-IR) of the lateral and basolateral amygdaloid nuclei 2-6 months post-stimulation. Male Sprague-Dawley rats were implanted with bipolar electrodes in the basolateral nucleus and stimulated once per day until 3-5 stage 5 seizures were observed. Coronal sections containing the amygdala were processed for GABA-IR using the contralateral side of the brain. Results indicate that, in comparison to controls, fully kindled animals showed a significant decrease in total number of GABA-IR amygdala neurons. Decreases in GABA-positive punctate structures surrounding unlabeled pyramidal cells were also observed, but not quantified. The present data suggest that epileptogenesis of the amygdala is associated with a significant reduction of GABA-IR in the lateral and basolateral areas throughout the contralateral amygdaloid nucleus.

引用

页码：335 / 339

页数：5

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