ABILITY OF CHOLINE AND ITS ANALOGS TO INTERACT WITH MUSCARINIC CHOLINERGIC RECEPTORS IN THE RAT-BRAIN

被引：29

作者：

SPETH, RC ^{[1
]}

YAMAMURA, HI ^{[1
]}

机构：

[1] UNIV ARIZONA,ARIZONA MED CTR,COLL MED,DEPT PHARMACOL,TUCSON,AZ 85724

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 58卷 / 02期

关键词：

Brain muscarinic receptors; Choline; Dimethylaminoethanol; Hemicholinium-3; [!sup]3[!/sup]H]Quinuclidinyl benzilate;

D O I：

10.1016/0014-2999(79)90012-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Choline displaced [3H]QNB binding from rat brain muscarinic receptors competitively, (Ki = 460 μM) but it was only 1/1000th as potent as ACh. Deanol was an extremely weak displacer of [3H]QNB binding while hemicholinium-3 was 50 times more potent than choline. Although brain levels of choline are well below its Ki value for muscarinic receptors, choline may directly interact with rat brain muscarinic receptors in some circumstances. © 1979.

引用

页码：197 / 201

页数：5

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