SYNTHESIS OF BRL 55834 - A NOVEL, POTENT AIRWAYS-SELECTIVE POTASSIUM CHANNEL ACTIVATOR

被引：17

作者：

BUCKLE, DR ^{[1
]}

EGGLESTON, DS ^{[1
]}

PINTO, IL ^{[1
]}

SMITH, DG ^{[1
]}

TEDDER, JM ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, DEPT PHYS & STRUCT CHEM, KING OF PRUSSIA, PA 19406 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)80639-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient synthesis of the potassium channel activator, BRL 55834 (2), is described and its absolute stereochemistry established as 3S,4R by X-ray crystallographic analysis of the corresponding (S)-alpha-methylbenzyl carbamate 12. BRL 55834 is the first compound of this pharmacological class to demonstrate selectivity for the smooth muscle of the airways compared with that of the vasculature.

引用

页码：1161 / 1164

页数：4

共 15 条

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