INTERACTION BETWEEN SUBSTANCE-P AND EXCITATORY AMINO-ACID RECEPTORS IN MODULATION OF NOCICEPTIVE RESPONSES OF CAT SPINAL DORSAL HORN NEURONS

被引：17

作者：

SONG, XJ ^{[1
]}

ZHAO, ZQ ^{[1
]}

机构：

[1] CHINESE ACAD SCI,SHANGHAI BRAIN RES INST,SHANGHAI 200031,PEOPLES R CHINA

来源：

NEUROSCIENCE LETTERS | 1994年 / 168卷 / 1-2期

关键词：

SUBSTANCE P; EXCITATORY AMINO ACID; ANTAGONIST; DORSAL HORN; NOCICEPTION;

D O I：

10.1016/0304-3940(94)90413-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Co-effects of microelectrophoretic application of 2-amino-5-phosphonovalerate (APV), ketamine, 6,7-dinitroqinoxaline-2,3-dione (DNQX), kynurenate (Kyn) and spantide on 34 spinal dorsal horn neurons were studied. Co-application of spantide and APV or DNQX produced a synergetic inhibition of responses by tibial stimulation in 10/23 and 3/8 neurons, respectively, and also in 3/8 neurons by administration of DL-sodium homocysteate. Spantide enhanced APV- or ketamine-induced inhibition of C responses of 8/19 neurons to sural stimulation, DNQX induced that of 2/4 neurons to gastrocnemius-soleous stimulation (GS), and Kyn induced that to both sural (8/19) and GS (2/4). The results suggest an interaction of SP and NMDA, non-NMDA receptors in processing spinal nociception.

引用

页码：49 / 52

页数：4

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