MONOCLONAL ANTI-BIOTIN ANTIBODIES SIMULATE AVIDIN IN THE RECOGNITION OF BIOTIN

被引：38

作者：

BAGCI, H

KOHEN, F

KUSCUOGLU, U

BAYER, EA

WILCHEK, M

机构：

[1] WEIZMANN INST SCI,DEPT BIOPHYS,IL-76100 REHOVOT,ISRAEL

[2] WEIZMANN INST SCI,DEPT HORMONE RES,IL-76100 REHOVOT,ISRAEL

来源：

FEBS LETTERS | 1993年 / 322卷 / 01期

关键词：

ANTI-BIOTIN ANTIBODY; ANTIBODY GENE; BIOTIN BINDING SITE; ANTIBODY COMBINING SITE; BINDING MOTIF;

D O I：

10.1016/0014-5793(93)81108-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sequence of the V(H) gene of a monoclonal anti-biotin antibody was determined. Biotin-binding motifs, similar to those in avidin and streptavidin, were identified in complementarity determining regions 2 and 3, suggesting that natural selection of functional motifs may occur in unrelated protein types.

引用

页码：47 / 50

页数：4

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