AN IMPROVED SYNTHESIS OF 8-BROMO-2'-DEOXYGUANOSINE

被引：26

作者：

GANNETT, PM

SURA, TP

机构：

[1] School of Pharmacy, West Virginia University, Morgantown, 265069530

来源：

SYNTHETIC COMMUNICATIONS | 1993年 / 23卷 / 11期

关键词：

D O I：

10.1080/00397919308011257

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of 8-bromo-2-deoxyguanosine, a key intermediate in the synthesis of the mutagenic DNA adduct 8-oxo-2'-deoxyguanosine is described. The advantages of this method are significantly improved yields and ease of isolation.

引用

页码：1611 / 1615

页数：5

共 9 条

[1] BRAMMER KW, 1963, BIOCHIM BIOPHYS ACTA, V72, P217
[2] N-15 NUCLEAR-MAGNETIC-RESONANCE STUDIES ON THE TAUTOMERISM OF 8-HYDROXY-2'-DEOXYGUANOSINE, 8-HYDROXYGUANOSINE, AND OTHER C8-SUBSTITUTED GUANINE NUCLEOSIDES
CHO, BP
KADLUBAR, FF
CULP, SJ
EVANS, FE
[J]. CHEMICAL RESEARCH IN TOXICOLOGY, 1990, 3 (05) : 445 - 452
[3] THE ROLE OF 8-HYDROXYGUANINE IN CARCINOGENESIS
FLOYD, RA
[J]. CARCINOGENESIS, 1990, 11 (09) : 1447 - 1450
[4] PURINE NUCLEOSIDES .7. DIRECT BROMINATION OF ADENOSINE DEOXYADENOSINE GUANOSINE + RELATED PURINE NUCLEOSIDES
HOLMES, RE
ROBINS, RK
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (06) : 1242 - &
[5] HYDROXYLATION OF GUANINE IN NUCLEOSIDES AND DNA AT THE C-8 POSITION BY HEATED GLUCOSE AND OXYGEN RADICAL-FORMING AGENTS
KASAI, H
NISHIMURA, S
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 1986, 67 : 111 - 116
[6] Kochetkov N.K., 1972, ORGANIC CHEM NUCLE B, P425
[7] 8-SUBSTITUTED GUANOSINE AND 2'-DEOXYGUANOSINE DERIVATIVES AS POTENTIAL INDUCERS OF THE DIFFERENTIATION OF FRIEND-ERYTHROLEUKEMIA CELLS
LIN, TS
CHENG, JC
ISHIGURO, K
SARTORELLI, AC
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (09) : 1194 - 1198
[8] SOLID-PHASE SYNTHESIS OF DNA FRAGMENTS CONTAINING THE MODIFIED BASE 7-HYDRO-8-OXO-2'-DEOXYGUANOSINE
ROELEN, HCPF
SARIS, CP
BRUGGHE, HF
VANDENELST, H
WESTRA, JG
VANDERMAREL, GA
VANBOOM, JH
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (16) : 4361 - 4369
[9] SHAPIRO R, 1966, BIOCHEM BIOPH RES CO, V23, P401

← 1 →