COMPARATIVE MOLECULAR-FIELD ANALYSIS OF BENZOPYRAN-4-CARBOTHIOAMIDE POTASSIUM CHANNEL OPENERS

被引：8

作者：

OHTA, M ^{[1
]}

KOGA, H ^{[1
]}

SATO, H ^{[1
]}

ISHIZAWA, T ^{[1
]}

机构：

[1] CHUGAI PHARMACEUT CO LTD, FUJI GOTEMBA RES LABS, GOTEMBA, SHIZUOKA 412, JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(01)80837-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Comparative molecular field analysis (CoMFA) was applied to 6-substituted benzopyran-4-carbothioamide potassium channel openers 1. CoMFA suggested that the electrostatic, steric, and hydrophobic factors of the 6-substituent were correlated with the vasorelaxant activity, among which the contribution of electrostatic factor was the most important.

引用

页码：2903 / 2906

页数：4

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