EFFECTS OF 17-BETA-ESTRADIOL, PROGESTERONE AND TAMOXIFEN ON INVITRO PROLIFERATION OF HUMAN PITUITARY-ADENOMAS - CORRELATION WITH SPECIFIC CELLULAR RECEPTORS

被引：25

作者：

CARONTI, B

PALLADINI, G

BEVILACQUA, MG

PETRANGELI, E

FRAIOLI, B

CANTORE, G

TAMBURRANO, G

CARAPELLA, CM

JAFFRAINREA, ML

机构：

[1] UNIV ROMA LA SAPIENZA,DEPT NEUROL SCI,I-00185 ROME,ITALY

[2] UNIV ROMA LA SAPIENZA,MED CLIN 2,INST ENDOCRINOL,I-00185 ROME,ITALY

[3] CNR,INST BIOMED TECHNOL,ROME,ITALY

[4] UNIV TOR VERGATA,INST NEUROSURG,ROME,ITALY

[5] REGINA ELANA HOSP,NEUROSURG SECT,ROME,ITALY

来源：

TUMOR BIOLOGY | 1993年 / 14卷 / 01期

关键词：

PITUITARY NEOPLASMS; CELL CULTURES; STEROID HORMONES; ANTIESTROGENS; STEROID RECEPTORS;

D O I：

10.1159/000217826

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Six human pituitary adenoma cultures, characterized for estrogen and progesterone (Pg) receptors, were treated with 17beta-estradiol (17beta-E2), Pg and tamoxifen (TAM) at different concentrations, alone and in combination, for 2, 4 and 8 days. Cell proliferation data showed in most cases a stimulating effect of 17beta-E2 and an inhibitory effect of Pg on cell growth, which appeared to be correlated with specific receptor expression, but independent of pituitary cell hormone content. A marked inhibitory effect of TAM on cell proliferation was present in all cases, but, on the contrary, was independent of estrogen receptor expression.

引用

页码：59 / 68

页数：10

共 36 条

[1] 17-BETA-ESTRADIOL HAS A BIPHASIC EFFECT ON GH CELL-GROWTH [J].