HIGHLY STEREOCONTROLLED ACCESS TO TRIFLUOROMETHYLBENZYLIC ALCOHOLS POSSESSING P-SUBSTITUENTS BY THE BAKERS-YEAST REDUCTION

被引：17

作者：

FUJISAWA, T

SUGIMOTO, T

SHIMIZU, M

机构：

[1] Department of Chemistry for Materials, Mie University, Tsu, Mie

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 06期

关键词：

D O I：

10.1016/0957-4166(94)80060-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The bakers' yeast reduction of p-amino- or hydroxy-substituted trifluoroacetylbenzene derivatives proceeded in a highly enantioselective manner to give (R)-trifluorobenzyl alcohols in up to 92 %ee, which is in a strong contrast to the results obtained in the cases with simple trifluoroacetylbenzene and the naphthalene analogues. The optically active alcohols obtained were readily converted into enantiomerically pure forms by recrystallization.

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页码：1095 / 1098

页数：4

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