THE ACTION OF SYNTHETIC CANNABINOIDS ON THE INDUCTION OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE

被引：55

作者：

COLLINS, DR ^{[1
]}

PERTWEE, RG ^{[1
]}

DAVIES, SN ^{[1
]}

机构：

[1] UNIV ABERDEEN, MARISCHAL COLL, DEPT BIOMED SCI, ABERDEEN AB9 1AS, SCOTLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 03期

关键词：

CANNABINOID; LONG-TERM POTENTIATION; HIPPOCAMPUS;

D O I：

10.1016/0014-2999(94)90666-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Incubation of rat hippocampal slices with the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation of field excitatory postsynaptic potentials recorded in the CA1 region. However, in slices incubated with its non-psychoactive(+)-isomer HU-211 (100 nM), which is reported to be an NMDA receptor antagonist, high frequency stimulation evoked a long-lasting potentiation, comparable to control slices.

引用

页码：R7 / R8

页数：2

共 8 条

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