THERAPEUTIC PROTEIN A IMMUNOADSORPTION - A REVIEW

被引：67

作者：

GJORSTRUP, P

WATT, RM

机构：

[1] Excorim KB, S-220 10 Lund

[2] DuPont, Glenolden Laboratory, Glenolden, PA 19036

来源：

TRANSFUSION SCIENCE | 1990年 / 11卷 / 3-4期

关键词：

D O I：

10.1016/0955-3886(90)90028-H

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Therapeutic immunoadsorption is the selective removal of immunoglobulins from patients in an extracorporeal circuit. The biochemical and structural properties of Staphylococcal protein A and its utility as an immobilized ligand for this application are reviewed. Utilizing it and an adsorption system that allows large quantities of IgG to be removed without the need for replacement fluids, patients with either autoimmune disease or those sensitized to alloantigens e.g. HLA antigens or factor VIII, have been treated. The immunological basis of each disease, the pathological role of antibody in the disease process, and the use of immunosuppressive therapies in the treatment of patients are discussed. A comparison of results collected during our studies and those obtained with plasmapheresis is offered where relevant.

引用

页码：281 / 302

页数：22

共 143 条

[1] Shoenfeld, Schwartz, Immunologic and genetic factors in autoimmune diseases, N Engl J Med, 311, pp. 1019-1029, (1984)
[2] Bottazzo, Todd, Mirakian, Belfiore, Pujol-Borrell, Organ-specific autoimmunity: a 1986 overview, Immunol Rev, 94, pp. 137-169, (1986)
[3] Gill, The natural history of factor VIII inhibitors in patients with hemophilia A, Factor VIII Inhibitors, pp. 19-29, (1984)
[4] Taube, Immunoadsorption in the sensitized transplant recipient, Kidney Int, 38, pp. 350-358, (1990)
[5] Shumak, Rock, Therapeutic plasma exchange, N Engl J Med, 310, pp. 762-771, (1984)
[6] Reimann, Mason, Plasmapheresis: technique and complications, Intensive Care Med, 16, pp. 3-10, (1990)
[7] Samtleben, Lysaght, Gurland, Therapeutic plasma exchange: achievements versus expectations, Contrib Nephrol, 44, pp. 223-235, (1985)
[8] Jones, Balint, Snyder, Selective extracorporeal removal of immunoglobulin-G and circulating immune complexes: a review, Plasma Ther Transfus Technol, 7, pp. 333-349, (1986)
[9] Virella, Glassman, Apheresis, exchange, adsorption and filtration of plasma: four approaches to the removal of undesirable circulating substances, Biomed Pharmacother, 40, pp. 286-296, (1986)
[10] Behn, Ivanovich, Klinkmann, Selective and specific adsorbents for medical therapy, Int J Artif Organs, 12, pp. 1-10, (1989)

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