THE SPECTRUM OF CLINICAL AND LABORATORY FINDINGS RESULTING FROM HUMAN HERPESVIRUS-6 (HHV-6) IN PATIENTS WITH MONONUCLEOSIS-LIKE ILLNESSES NOT RESULTING FROM EPSTEIN-BARR-VIRUS OR CYTOMEGALOVIRUS
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STEEPER, TA
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机构:METROPOLITAN MT SINAI MED CTR,DEPT LAB MED,MINNEAPOLIS,MN 55404
STEEPER, TA
HORWITZ, CA
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机构:METROPOLITAN MT SINAI MED CTR,DEPT LAB MED,MINNEAPOLIS,MN 55404
HORWITZ, CA
ABLASHI, DV
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机构:METROPOLITAN MT SINAI MED CTR,DEPT LAB MED,MINNEAPOLIS,MN 55404
ABLASHI, DV
SALAHUDDIN, SZ
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机构:METROPOLITAN MT SINAI MED CTR,DEPT LAB MED,MINNEAPOLIS,MN 55404
SALAHUDDIN, SZ
SAXINGER, C
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SAXINGER, C
SALTZMAN, R
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SALTZMAN, R
SCHWARTZ, B
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SCHWARTZ, B
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[1] METROPOLITAN MT SINAI MED CTR,DEPT LAB MED,MINNEAPOLIS,MN 55404
Recently, the morphologic, immunologic, and molecular makeup of a new virus designated human herpesvirus-6 (HHV-6) has been described. Because cell cultures of HHV-6-infected mononuclear cells showed prominent lymphocytic changes, it could be anticipated that mononucleosis-like illnesses or lymphoproliferative disorders would turn out to be manifestations of active HHV-6 infection. In the present study, blood samples from 27 patients previously categorized as having non-Epstein-Barr virus (non-EBV)/noncytomegalovirus (non-CMV) heterophil-negative mononucleosis-like illnesses were tested for IgM and IgG antibodies to HHV-6. Eight of these patients (30%) had serologic evidence of active HHV-6 infection. The clinical spectrum includes a short-lived febrile illness, mild cervical lymphadenopathy, laboratory data suggestive of active viral hepatitis in two patients, and a prolonged febrile illness in a single patient with previously documented positive anti-HIV serology. The viral studies revealed the presence of fourfold HHV-6-specific IgG titer increases by immunofluorescent assay (IFA) in seven serially studied cases and positive IgM serology on one or more samples tested by IFA or enzyme-linked immunosorbent assay (ELISA) in all eight cases. The authors could not determine whether the illnesses represented primary HHV-6 infections in susceptible individuals or reactivation of latent virus. HHV-6 serologic studies may be indicated in patients with mononucleosis-like illnesses with atypical lymphocytosis when EBV and CMV test results are nondiagnostic.