TOXIC INTERACTION BETWEEN FLUVOXAMINE AND SUSTAINED-RELEASE THEOPHYLLINE IN AN 11-YEAR-OLD BOY

被引：77

作者：

SPERBER, AD ^{[1
]}

机构：

[1] SOROKA MED CTR,INST GASTROENTEROL,DIV INTERNAL MED,IL-84101 BEER SHEVA,ISRAEL

来源：

DRUG SAFETY | 1991年 / 6卷 / 06期

关键词：

D O I：

10.2165/00002018-199106060-00006

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

An 11-year-old boy with asthma had been receiving a controlled release theophylline preparation. He was prescribed fluvoxamine for a depressive disorder and within a week complained of severe headaches, tiredness and vomiting. His serum theophylline concentration had increased from 14.2 mg/L (shortly before fluvoxamine was started) to 27.4 mg/L. Fluvoxamine was withdrawn and theophylline concentrations decreased. Clomipramine was substituted for fluvoxamine with no further problems and a later theophylline concentration was 13.7 mg/L. Competitive inhibition of hepatic microsomal enzymes by fluvoxamine may have been responsible for the elevated theophylline concentrations and toxicity observed in this case.

引用

页码：460 / 462

页数：3

共 11 条

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