INHIBITORY EFFECT OF INHALED PROCATEROL ON ANAPHYLACTIC BRONCHOCONSTRICTION AND THROMBOXANE-A2 PRODUCTION IN GUINEA-PIGS

被引：24

作者：

FUJIMURA, M

SAKAMOTO, S

NISHI, K

SAITO, M

MIYAKE, Y

MATSUDA, T

机构：

[1] III Dept. of Int. Medicine, Kanazawa University, School of Medicine, Kanazawa 920

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 1991年 / 21卷 / 02期

关键词：

D O I：

10.1111/j.1365-2222.1991.tb00829.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This study was designed to examine whether an inhaled beta-2-agonist, procaterol, inhibits thromboxane A2 (TXA2) production induced by antigen challenge in passively sensitized guinea-pigs in vivo. Antigen-induced bronchoconstriction was markedly inhibited by pre-treatment with procaterol. Inhaled procaterol significantly reduced in a dose-dependent manner the increment in TXB2 concentration in bronchoalveolar lavage fluid obtained 5 min after antigen challenge. Aerosol administration of procaterol significantly inhibited bronchoconstriction induced by inhaled histamine. These results suggest that inhalation of procaterol has an inhibitory effect on antigen-induced TXA2 production as well as a protective effect against bronchoconstriction induced by bronchoactive agents.

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收藏

页码：189 / 194

页数：6

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