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ON THE RAT MODEL OF HUMAN OSTEOPENIAS AND OSTEOPOROSIS

被引：373
作者：
FROST, HM
JEE, WSS
机构：
[1] UNIV UTAH, SCH MED, DIV RADIOBIOL, BLDG 586, SALT LAKE CITY, UT 84112 USA
[2] SO COLORADO CLIN, DEPT ORTHOPAED SURG, PUEBLO, CO USA
来源：
BONE AND MINERAL | 1992年 / 18卷 / 03期
关键词：
RAT; OSTEOPOROSIS; OSTEOPENIA; BONE MODELING; BONE REMODELING; MECHANICAL AND NONMECHANICAL AGENTS;
D O I：
10.1016/0169-6009(92)90809-R
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The idea that rats cannot model human osteopenias errs. The same mechanisms control gains in bone mass (longitudinal bone growth and modeling drifts) and losses (BMU-based remodeling), in young and aged rats and humans. Furthermore, they respond similarly in rats and man to mechanical influences, hormones, drugs and other agents.
引用
收藏
页码：227 / 236
页数：10
相关论文
共 98 条
  • [1] ADAMS ME, 1982, BONE JOINT DISEASE, P265
  • [2] ARNOLD J. S., 1966, CLIN ORTHOP RELATED RES, V49, P17
  • [3] ARNOLD JS, 1981, BONE HISTOMORPHOMETR, P297
  • [4] BARENGOLTS EI, 1991, CELLS MAT S1, V1, P105
  • [5] EVIDENCE OF SEQUENTIAL REMODELING IN RAT TRABECULAR BONE - MORPHOLOGY, DYNAMIC HISTOMORPHOMETRY, AND CHANGES DURING SKELETAL MATURATION
    BARON, R
    TROSS, R
    VIGNERY, A
    [J]. ANATOMICAL RECORD, 1984, 208 (01): : 137 - 145
  • [6] ERRORS IN BONE REMODELING - TOWARD A UNIFIED THEORY OF METABOLIC BONE-DISEASE
    BURR, DB
    MARTIN, RB
    [J]. AMERICAN JOURNAL OF ANATOMY, 1989, 186 (02): : 186 - 216
  • [7] PATHOPHYSIOLOGICAL MECHANISMS OF ESTROGEN EFFECT ON BONE METABOLISM - DOSE-RESPONSE RELATIONSHIPS IN EARLY POST-MENOPAUSAL WOMEN
    CHRISTIANSEN, C
    CHRISTENSEN, MS
    LARSEN, NE
    TRANSBOL, IB
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1982, 55 (06) : 1124 - 1130
  • [8] CORNELL CN, 1992, CLIN ORTHOP RELAT R, V277, P297
  • [9] ABNORMALITIES IN FRACTURE-HEALING INDUCED BY VITAMIN-B6-DEFICIENCY IN RATS
    DODDS, RA
    CATTERALL, A
    BITENSKY, L
    CHAYEN, J
    [J]. BONE, 1986, 7 (06) : 489 - 495
  • [10] METABOLIC CHANGES IN THE CELLS OF THE CALLUS DURING FRACTURE-HEALING IN THE RAT
    DUNHAM, J
    CATTERALL, A
    BITENSKY, L
    CHAYEN, J
    [J]. CALCIFIED TISSUE INTERNATIONAL, 1983, 35 (01) : 56 - 61
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