ANTIOXIDANT ERYTHROCYTE ENZYME-ACTIVITIES DURING ORAL CONTRACEPTION

被引：26

作者：

MASSAFRA, C ^{[1
]}

BUONOCORE, G ^{[1
]}

BERNI, S ^{[1
]}

GIOIA, D ^{[1
]}

GIULIANI, A ^{[1
]}

VEZZOSI, P ^{[1
]}

机构：

[1] UNIV SIENA,DIV NEONATOL,I-53100 SIENA,ITALY

来源：

CONTRACEPTION | 1993年 / 47卷 / 06期

关键词：

D O I：

10.1016/0010-7824(93)90026-4

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Nineteen healthy young women, non-smokers and of normal weight, used a combined oral contraceptive, consisting of 20 mug ethinylestradiol and 150 mug desogestrel, for 9 cycles and were investigated before starting oral contraceptive use, and during the 3rd, 6th and 9th cycle. In all cases, the antioxidant erythrocyte enzyme activities, superoxide-dismutase (SOD), catalase (CAT) and glutathione-peroxidase (GSH-Px), were determined. Pyruvate-kinase (PK) activity was also considered as a predictable index of the age and constancy of the erythrocyte population. A steady, significant increase in GSH-Px and CAT enzyme activities was found. No significant variations were found in SOD and PK enzyme levels. These findings clearly suggest that the use of combined oral contraceptives leads to an increase in antioxidant defenses. The specific physiological and biochemical mechanisms of this response merit further investigation.

引用

页码：591 / 596

页数：6

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