BIODEGRADABLE MICROPARTICLES FOR ORAL IMMUNIZATION

被引:120
作者
OHAGAN, DT
MCGEE, JP
HOLMGREN, J
MOWAT, AMCL
DONACHIE, AM
MILLS, KHG
GAISFORD, W
RAHMAN, D
CHALLACOMBE, SJ
机构
[1] GOTHENBURG UNIV, DEPT MED MICROBIOL & IMMUNOL, S-41346 GOTHENBURG, SWEDEN
[2] WESTERN INFIRM & ASSOCIATED HOSP, DEPT IMMUNOL, GLASGOW G11 6NT, SCOTLAND
[3] NATL INST BIOL STAND & CONTROLS, S MIMMS EN6 3QG, HERTS, ENGLAND
[4] GUYS HOSP, DEPT ORAL MED & PATHOL, LONDON SE1 9RT, ENGLAND
关键词
BIODEGRADABLE MICROPARTICLES; VACCINE; OVALBUMIN; CHOLERA TOXIN;
D O I
10.1016/0264-410X(93)90011-L
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Ovalbumin (OVA) was entrapped in poly(lactide-co-glycolide) microparticles and administered to mice. Following intraperitoneal immunization, the microparticles induced both proliferative T-cell responses and cytotoxic T-cell responses in spleen cells. Following oral immunization, the mean salivary IgA antibody response to microparticles was significantly greater than the response to soluble OVA (p < 0.0001). Serum IgG antibody levels were also significantly greater in the group administered microparticles (p < 0.001). Cholera toxin B subunit was also entrapped in microparticles. Following oral immunization in mice, specific antibody-secreting cells were detected both in the spleens and in the mesenteric lymph nodes.
引用
收藏
页码:149 / 154
页数:6
相关论文
共 18 条
[1]   VACCINES FOR THE THIRD-WORLD [J].
BLOOM, BR .
NATURE, 1989, 342 (6246) :115-120
[2]   SYSTEMIC TOLERANCE AND SECRETORY IMMUNITY AFTER ORAL IMMUNIZATION [J].
CHALLACOMBE, SJ ;
TOMASI, TB .
JOURNAL OF EXPERIMENTAL MEDICINE, 1980, 152 (06) :1459-1472
[3]   SALIVARY ANTIBODIES AND SYSTEMIC TOLERANCE IN MICE AFTER ORAL IMMUNIZATION WITH BACTERIAL-ANTIGENS [J].
CHALLACOMBE, SJ .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1983, 409 (JUN) :177-193
[4]   ORAL-ADMINISTRATION OF A STREPTOCOCCAL ANTIGEN COUPLED TO CHOLERA-TOXIN B-SUBUNIT EVOKES STRONG ANTIBODY-RESPONSES IN SALIVARY-GLANDS AND EXTRAMUCOSAL TISSUES [J].
CZERKINSKY, C ;
RUSSELL, MW ;
LYCKE, N ;
LINDBLAD, M ;
HOLMGREN, J .
INFECTION AND IMMUNITY, 1989, 57 (04) :1072-1077
[5]   THE PREPARATION AND CHARACTERIZATION OF POLY(LACTIDE-CO-GLYCOLIDE) MICROPARTICLES .1. OIL-IN-WATER EMULSION SOLVENT EVAPORATION [J].
JEFFERY, H ;
DAVIS, SS ;
OHAGAN, DT .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1991, 77 (2-3) :169-175
[6]  
JEFFERY H, 1993, IN PRESS PHARM RES
[7]   CELLULAR AND HUMORAL IMMUNE-RESPONSES TO POLIOVIRUS IN MICE - A ROLE FOR HELPER T-CELLS IN HETEROTYPIC IMMUNITY TO POLIOVIRUS [J].
KATRAK, K ;
MAHON, BP ;
MINOR, PD ;
MILLS, KHG .
JOURNAL OF GENERAL VIROLOGY, 1991, 72 :1093-1098
[8]  
MAULDING H V, 1987, Journal of Controlled Release, V6, P167, DOI 10.1016/0168-3659(87)90074-5
[9]  
MOWAT AM, 1991, IMMUNOLOGY, V72, P317
[10]  
O'HAGAN D T, 1990, Advanced Drug Delivery Reviews, V5, P265, DOI 10.1016/0169-409X(90)90020-S