A DIPEPTIDYLPEPTIDASE SECRETED BY FASCIOLA-HEPATICA

被引：22

作者：

CARMONA, C

MCGONIGLE, S

DOWD, AJ

SMITH, AM

COUGHLAN, S

MCGOWRAN, E

DALTON, JP

机构：

[1] DUBLIN CITY UNIV,SCH BIOL SCI,DUBLIN 9,IRELAND

[2] UNIV REPUBLICA,INST HIGIENE,UNIDAD BIOL PARASITARIA,MONTEVIDEO,URUGUAY

来源：

PARASITOLOGY | 1994年 / 109卷

关键词：

LIVER FLUKE; FASCIOLA HEPATICA; TREMATODA; DIPEPTIDYLPEPTIDASE; EXOPEPTIDASE;

D O I：

10.1017/S0031182000077817

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

A dipeptidylpeptidase (DPP) was isolated from Fasciola hepatica by gel-filtration and ion-exchange chromatography. The exoproteinase is secreted by newly excysted juveniles, immature and mature flukes. The liver fluke DPP is a serine proteinase of molecular weight > 200 kDa and differs from previously characterized mammalian DPPs in its substrate preference and susceptibility to inactivation by inhibitors. The parasite DPP may function in the latter stages of the proteolytic digestion of host macromolecules. In this manner, the enzyme may be important in providing the parasite with dipeptides that could be absorbed through the intestine as nutrient.

引用

页码：113 / 118

页数：6

共 13 条

[1] FLUORESCENT HISTOCHEMISTRY OF ACID PROTEASES IN ADULT SCHISTOSOMA-MANSONI AND SCHISTOSOMA-JAPONICUM [J].