INTRACELLULAR PH DURING CHEMICAL HYPOXIA IN CULTURED RAT HEPATOCYTES - PROTECTION BY INTRACELLULAR ACIDOSIS AGAINST THE ONSET OF CELL-DEATH

被引:243
作者
GORES, GJ [1 ]
NIEMINEN, AL [1 ]
WRAY, BE [1 ]
HERMAN, B [1 ]
LEMASTERS, JJ [1 ]
机构
[1] UNIV N CAROLINA,SCH MED,DEPT CELL BIOL & ANAT,CELL BIOL LABS,CAMPUS BOX 7090,108 SWING BLDG,CHAPEL HILL,NC 27599
关键词
D O I
10.1172/JCI113896
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:386 / 396
页数:11
相关论文
共 42 条
[1]   RESPONSE OF ISOLATED RAT-HEART CELLS TO HYPOXIA, RE-OXYGENATION, AND ACIDOSIS [J].
ALTSCHULD, RA ;
HOSTETLER, JR ;
BRIERLEY, GP .
CIRCULATION RESEARCH, 1981, 49 (02) :307-316
[2]   MITOCHONDRIAL TRANSMEMBRANE POTENTIAL AND PH GRADIENT DURING ANOXIA [J].
ANDERSSON, BS ;
AW, TY ;
JONES, DP .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (04) :C349-C355
[3]   USE OF DIGITONIN FRACTIONATION TO DETERMINE MITOCHONDRIAL TRANSMEMBRANE ION DISTRIBUTION IN CELLS DURING ANOXIA [J].
ANDERSSON, BS ;
JONES, DP .
ANALYTICAL BIOCHEMISTRY, 1985, 146 (01) :164-172
[4]   FRUCTOSE PREVENTS HYPOXIC CELL-DEATH IN LIVER [J].
ANUNDI, I ;
KING, J ;
OWEN, DA ;
SCHNEIDER, H ;
LEMASTERS, JJ ;
THURMAN, RG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (03) :G390-G396
[5]   SUPPRESSION OF MITOCHONDRIAL RESPIRATORY-FUNCTION AFTER SHORT-TERM ANOXIA [J].
AW, TY ;
ANDERSSON, BS ;
JONES, DP .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (04) :C362-C368
[6]   MITOCHONDRIAL TRANSMEMBRANE ION DISTRIBUTION DURING ANOXIA [J].
AW, TY ;
ANDERSSON, BS ;
JONES, DP .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (04) :C356-C361
[7]   HEART-MUSCLE VIABILITY FOLLOWING HYPOXIA - PROTECTIVE EFFECT OF ACIDOSIS [J].
BING, OHL ;
BROOKS, WW ;
MESSER, JV .
SCIENCE, 1973, 180 (4092) :1297-1298
[8]   SUPPORT OF CULTURED-HEPATOCYTES BY A LAMININ-RICH GEL - EVIDENCE FOR A FUNCTIONALLY SIGNIFICANT SUBENDOTHELIAL MATRIX IN NORMAL RAT-LIVER [J].
BISSELL, DM ;
ARENSON, DM ;
MAHER, JJ ;
ROLL, FJ .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (03) :801-812
[9]   EFFECTS OF METABOLIC-ACIDOSIS ON VIABILITY OF CELLS EXPOSED TO ANOXIA [J].
BONVENTRE, JV ;
CHEUNG, JY .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 249 (01) :C149-C159
[10]  
BRANDFORD CB, 1987, J BIOL CHEM, V262, P5057