EFFECTS OF METHYLENEDIOXYMETHAMPHETAMINE ON THE RELEASE OF MONOAMINES FROM RAT-BRAIN SLICES

被引：59

作者：

FITZGERALD, JL

REID, JJ

机构：

[1] Department of Pharmacology, University of Melbourne, Melbourne

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 191卷 / 02期

关键词：

5-HT; (5-hydroxytryptamine; serotonin); Brain slices (rat; superfused); Dopamine; MDMA (3,4-methylenedioxymethamphetamine); Monoamine release; Noradrenaline;

D O I：

10.1016/0014-2999(90)94150-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamine release were investigated in superfused slices of rat striatum and hippocampus. MDMA (10 μM) increased the resting release of radioactivity from slices incubated in [3H]dopamine, [3H]5-hydroxytryptamine or [3H]noradrenaline. These effects of MDMA (10 μM) were blocked by the neuronal uptake inhibitors, cocaine (10 μM), fluoxetine (1 μM) and desmethylhnipramine (1 μM), respectively. MDMA (10 μM) enhanced the stimulation-induced efflux of radioactivity from slices incubated in [3H]noradrenaline but not from slices incubated in [3H]5-hydroxytryptamine or [3H]dopamine. These results demonstrate for the first time a direct noradrenaline-releasing action of MDMA and differential effects of MDMA on the stimulation-induced release of noradrenaline, dopamine and 5-hydroxytryptamine from rat superfused brain slices. © 1990.

引用

页码：217 / 220

页数：4

共 9 条

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