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THE PHARMACOLOGY OF METHOTREXATE

被引：125
作者：
OLSEN, EA
机构：
[1] Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham, North Carolina
来源：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1991年 / 25卷 / 02期
关键词：
D O I：
10.1016/0190-9622(91)70199-C
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population. With the appropriate knowledge of the importance of urinary excretion of methotrexate and factors that influence this and with the ready availability of leucovorin, toxicity can be avoided in all but the most unusual of circumstances.
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收藏
页码：306 / 318
页数：13
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