RELAXANT EFFECT OF RAT PHI, PHI-GLY AND PHV(1-42) IN THE RAT GASTRIC FUNDUS

被引：16

作者：

LEFEBVRE, RA ^{[1
]}

SAS, S ^{[1
]}

CAUVIN, A ^{[1
]}

机构：

[1] UNIV LIBRE BRUXELLES,SCH MED,DEPT BIOCHEM & NUTR,B-1000 BRUSSELS,BELGIUM

来源：

PEPTIDES | 1991年 / 12卷 / 02期

关键词：

GASTRIC FUNDUS; RAT; RELAXATION; VIP; PHI;

D O I：

10.1016/0196-9781(91)90010-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It was previously shown that porcine PHI is 30 times less potent than VIP in relaxing the rat gastric fundus; the relaxant potency of rat PHI and its 2 C-terminally extended forms PHI-Gly and pHV(1-42) in the rat gastric fundus was compared here with that of VIP, porcine PHI and PHM. The rank order of potency in relaxing the precontracted fundus tissues was VIP > rat PHI > PHM > PHV > PHI-Gly > porcine PHI, rat PHI being only 2 times less potent than VIP. In the presence of antioxidants, the potency and efficacy of porcine PHI increased, but the peptide was still the least potent of the series tested. The results illustrate the importance of using species-related peptides and are compatible with a contransmitter role of rat PHI in nonadrenergic noncholinergic neurotransmission of the rat gastric fundus.

引用

页码：271 / 274

页数：4

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