MICROBIAL TRANSFORMATION OF IMMUNOSUPPRESSIVE COMPOUNDS .1. DESMETHYLATION OF FK506 AND IMMUNOMYCIN (FR-900520) BY ACTINOPLANES SP ATCC-53771

被引：23

作者：

CHEN, TS

ARISON, BH

WICKER, LS

INAMINE, ES

MONAGHAN, RL

机构：

[1] The Merck Sharp & Dohme Research Laboratory, New Jersey 07065, P.O. Box 2000, Rahway

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 01期

关键词：

D O I：

10.7164/antibiotics.45.118

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The immunosuppressants FK506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.

引用

页码：118 / 123

页数：6

共 7 条

[1]

BORRIS RP, 30TH ANN M AM SOC PH

[2]

DUMONT FJ, 1990, J IMMUNOL, V144, P251

[3]

GOTO T, 1987, TRANSPLANT P, V19, P4

[4]

HATANAKA H, 1988, J ANTIBIOT, V41, P1586, DOI 10.7164/antibiotics.41.1586

[5]

HATANAKA H, 1988, Journal of Antibiotics (Tokyo), V41, P1592

[6] FK-506, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM A STREPTOMYCES .1. FERMENTATION, ISOLATION, AND PHYSICOCHEMICAL AND BIOLOGICAL CHARACTERISTICS [J].

KINO, T ;

HATANAKA, H ;

HASHIMOTO, M ;

NISHIYAMA, M ;

GOTO, T ;

OKUHARA, M ;

KOHSAKA, M ;

AOKI, H ;

IMANAKA, H .

JOURNAL OF ANTIBIOTICS, 1987, 40 (09) :1249-1255

[7] STRUCTURE OF FK506 - A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM STREPTOMYCES [J].

TANAKA, H ;

KURODA, A ;

MARUSAWA, H ;

HATANAKA, H ;

KINO, T ;

GOTO, T ;

HASHIMOTO, M ;

TAGA, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (16) :5031-5033

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