EARLY CHANGES OF ALPHA-B-CRYSTALLIN MESSENGER-RNA IN RAT SKELETAL-MUSCLE TO MECHANICAL TENSION AND DENERVATION

被引：47

作者：

ATOMI, Y ^{[1
]}

YAMADA, S ^{[1
]}

NISHIDA, T ^{[1
]}

机构：

[1] OTSUKA PHARMACEUT CO LTD,CELL TECHNOL LAB,TOKUSHIMA 84201,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 181卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)92083-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

αB-Crystallin specifically decreases in atrophied rat soleus muscle with hindlimb suspension (HS). αB-Crystallin cDNA was cloned from rat heart cDNA library using oligonucletide probe, and its complete coding and partial non-coding regions were sequenced. Northern blot analysis revealed that αB-crystallin mRNA in slow muscle decreases at 36 hour after HS but recovered at 24 hour after HS stopped. Denervation decreased the expression of αB-crystallin mRNA in slow muscle but increased it in fast muscles, which hardly expressed in normal condition. Passive tension increased the expression of αB-crystallin mRNA in both muscle types. Based upon these Northern blot analysis of αB-crystallin, nerve innervation and external load on muscle are essential regulatory factors on the expression of the mRNA of αB-crystallin in rat skeletal muscle. © 1991.

引用

页码：1323 / 1330

页数：8

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