HLA DETERMINANTS IN FAMILIAL MULTIPLE-SCLEROSIS

被引：15

作者：

GRASSO, MG ^{[1
]}

CUTRUPI, F ^{[1
]}

BERNARDI, S ^{[1
]}

TRABACE, S ^{[1
]}

POZZILLI, C ^{[1
]}

CAPPELLACCI, S ^{[1
]}

FIESCHI, C ^{[1
]}

机构：

[1] UNIV ROME, CATTEDRA GENET MED, DEPT EXPTL MED, I-00100 ROME, ITALY

来源：

NEUROEPIDEMIOLOGY | 1992年 / 11卷 / 02期

关键词：

MULTIPLE SCLEROSIS; FAMILIES; HLA;

D O I：

10.1159/000110916

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

HLA-A, -B, -C, -DR, -DQ antigens were studied in 11 multiplex MS families, 11 single-case MS families and 100 healthy subjects. The HLA DR4 was the most frequent antigen in all MS patients (p = 0.015). When the antigenic frequency in index familial cases was compared with that in single cases, the DR4 antigen was found to be more frequent (p = 0.01) in familial cases only. Furthermore, when the DR4 antigen was excluded from the analysis, we observed an increase in DR2 (p = 0.11) only in the familial MS cases. These results can be compatible with a multifactorial hypothesis according to which the HLA genes have an important role in MS susceptibility in familial cases.

引用

页码：85 / 89

页数：5

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