PSYCHOACTIVITY AND ABUSE POTENTIAL OF SUMATRIPTAN

被引:34
作者
SULLIVAN, JT
PRESTON, KL
TESTA, MP
BUSCH, M
JASINSKI, DR
机构
[1] GLAXO PHARMACEUT,RES TRIANGLE PK,NC
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205
关键词
D O I
10.1038/clpt.1992.202
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Sumatriptan is a 5-HT1D agonist of therapeutic use in migraine and cluster headaches. To determine the profile of psychoactivity and abuse potential, a double-blind Latin-square crossover study was conducted in 12 male subjects with histories of substance abuse. The effects of subcutaneous placebo, sumatriptan (8 and 16 mg), and morphine (10 and 20 mg) were assessed on measures of subjective, behavioral, and physiologic responses including signs, symptoms, Addiction Research Center Inventory scales, onset of drug effects and miosis. Sumatriptan was psychoactive, was discriminated from placebo, produced a dose-related decrease on euphoria scores, elevated scores on measures of apathetic sedation and disliking, and lacked identification as a prototypic drug of abuse. There were no clinically significant effects on heart rate, pupil size, or blood pressure. In contrast, morphine (the positive control) produced expected dose-response relationships on measures of reinforcing and physiologic effects. The study suggests that sumatripitan has a low abuse potential.
引用
收藏
页码:635 / 642
页数:8
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